Metabolomics core facility
The metabolomics core facility provides knowhow
- on metabolomics experiment design,
- performs mass-spectrometry based analyzes of metabolites/metabolic profiles and
- can also help with the analysis of metabolomics data.
What exactly does “metabolomics” mean?
Metabolomics covers a variety of different approaches for studies of low molecular weight compounds in biological systems. Lipids, amino acids, nucleobases, organic acids, alkaloids, low molecular weight drugs and many others are covered by the “metabolite” umbrella term. Short peptides with a few amino acids in length can also be included, but longer peptides, proteins, nucleic acids and oligosaccharides require specific methods not typically used in metabolomics.
Metabolomics is usually done with nuclear magnetic resonance or mass spectrometry. The latter is more sensitive and allows a wider variety of specific analyses, but has the drawback of not being properly quantitative per se. Quantitative values for specific metabolites can be achieved using internal and external standards.
In our core facility we use mass-spectrometry approach for metabolomics studies.