Neurodegenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s etc.) represent an increasing threat to public health in addition to their assault upon the lives of patients and their families. In most cases, the pathogenesis of these diseases has remained obscure and treatment strategies inadequate. However, recent lines of evidence suggest strong mitochondrial involvement in these diseases – defects in mitochondrial autophagy, dynamics or/and biogenesis have now been recognized as clearly associated with the pathogenesis of these diseases. We would like to further study some of these links and to determine whether these pathways could be used activate neuronal repair mechanisms. Thus, we expect that we will contribute to the common goal of uncovering the neurobiological basis of neurodegenerative diseases and may help to uncover, in the longer run, new treatments for with neurodegenerative diseases.
Specific research topics:
- Role of Miro proteins in neuronal mitophagy
- Link between mitochondrial fusioon and fission dynamics in neuronal mitophagy
- Mitochondrial biogenesis in neurodegeneration