Neural cell adhesion molecules as potential therapeutic targets for the treatment of the dysfunctional brain plasticity in psychiatric and neurodegenerative diseases
The goal of the current research project is a better understanding of the cellular and molecular mechanisms of neurodegeneration and dysfunctional brain plasticity focusing on the neural cell adhesion molecules and discover new diagnostic and treatment possibilities to combat neurodegenerative and psychotic disorders. This project is mainly focused on 1) elucidation of the mechanisms regulating the polysialylation of NCAM in physiological and pathological conditions, 2) exploration NCAM as a diagnostic and treatment efficacy biomarker of neurodegenerative diseases, 3) exploration of the therapeutic potential on the novel drug candidates aiming at restoring impaired brain plasticty focusing on NCAM mimetics, neurotrophin receptor agonists, metalloproteinases and endopeptidase inhibitors on the selected in vitro and in vivo models.
The effect of epigenetic modifiers to reverse cocaine-induced behavioural sensitization
The aim of the research proposal is to study the role of epigenetic modifications (especially DNA methylation and demethylation) in the drug addiction related mechanisms, to evaluate the epigenetics modifying enzymes as possible target of drug addiction treatment. Future plans are to study more generally the involvement of epigenetic mechanism in pharmacokinetics (pharmacoepigenetics) and pharmacodynamics of psychiatric and neurological medications.