Research areas | Institute of Biomedicine and Translational Medicine, University of Tartu

Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    Lossi 3, 51003 Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
    Faculty address: 
    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
Faculty address: 
Lossi 36, 51003 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
    +372 737 6440
    Faculty address: 
    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
    Faculty phone: 
    +372 737 5582
    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
    Faculty phone: 
    +372 737 6310
    Faculty address: 
    J. Liivi 4, 50409 Tartu
  • Institute of Psychology
    Faculty phone: 
    +372 737 5902
    Faculty address: 
    Näituse 2, 50409 Tartu
  • School of Law
    Faculty phone: 
    +372 737 5390
    Faculty address: 
    Näituse 20–324, 50409 Tartu
  • Institute of Social Studies
    Faculty phone: 
    +372 737 5188
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Narva College
    Faculty phone: 
    +372 740 1900
    Faculty address: 
    Raekoja plats 2, 20307 Narva
  • Pärnu College
    Faculty phone: 
    +372 445 0520
    Faculty address: 
    Ringi 35, 80012 Pärnu
Faculty of Medicine
Faculty phone: 
+372 737 5326
Faculty address: 
Ravila 19, 50411 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5326
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Biomedicine and Translational Medicine
    Faculty phone: 
    +372 737 4210
    Faculty address: 
    Biomeedikum, Ravila 19, 50411 Tartu
  • Institute of Pharmacy
    Faculty phone: 
    +372 737 5286
    Faculty address: 
    Nooruse 1, 50411 Tartu
  • Institute of Dentistry
    Faculty phone: 
    +372 731 9856
    Faculty address: 
    Raekoja plats 6, 51003 Tartu
  • Institute of Clinical Medicine
    Faculty phone: 
    +372 737 5323
    Faculty address: 
    L. Puusepa 8, 50406 Tartu
  • Institute of Family Medicine and Public Health
    Faculty phone: 
    +372 737 4190
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
    Faculty phone: 
    +372 737 5360
    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
Faculty phone: 
+372 737 5820
Faculty address: 
Vanemuise 46–208, 51014 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5820
    Faculty address: 
    Vanemuise 46–208, 51005 Tartu
  • Institute of Computer Science
    Faculty phone: 
    +372 737 5445
    Faculty address: 
    J. Liivi 2, 50409 Tartu
  • Estonian Marine Institute
    Faculty phone: 
    +372 671 8902
    Faculty address: 
    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
    Faculty phone: 
    +372 737 5261
    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Mathematics and Statistics
    Faculty phone: 
    +372 737 5860
    Faculty address: 
    J. Liivi 2, 50409 Tartu
  • Institute of Molecular and Cell Biology
    Faculty phone: 
    +372 737 5011
    Faculty address: 
    Riia 23, 23b–134, 51010 Tartu
  • Tartu Observatory
    Faculty phone: 
    +372 737 4510
    Faculty address: 
    Observatooriumi 1, Tõravere, 61602 Tartumaa
  • Institute of Technology
    Faculty phone: 
    +372 737 4800
    Faculty address: 
    Nooruse 1, 50411 Tartu
  • Institute of Ecology and Earth Sciences
    Faculty phone: 
    +372 737 5835
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Institutions
  • Library
    Faculty phone: 
    +372 737 5702
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
    Faculty phone: 
    +372 737 5581
    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Institute of Genomics
    Faculty phone: 
    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Museum
    Faculty phone: 
    +372 737 5674
    Faculty address: 
    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
    Faculty phone: 
    +372 737 6076
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
  • Administrative Office
    Faculty phone: 
    +372 737 5606
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Centre for Entrepreneurship and Innovation
    Faculty phone: 
    +372 737 6339
    Faculty address: 
    Lossi 3, III floor, 51003 Tartu
  • University Office in Tallinn
    Faculty phone: 
    +372 737 6600
    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
    Faculty phone: 
    +372 737 5137
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
    Faculty phone: 
    +372 737 5125
    Faculty address: 
    Jakobi 4, 51005 Tartu
  • Grant Office
    Faculty phone: 
    +372 737 6215
    Faculty address: 
    Lossi 3, III floor, 51003 Tartu
  • Information Technology Office
    Faculty phone: 
    +372 737 6000, IT-help: +372 737 5500
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Human Resources Office
    Faculty phone: 
    +372 737 5145
    Faculty address: 
    Ülikooli 18, rooms 302 and 304, 50090 Tartu
  • Internal Audit Office
    Faculty address: 
    Ülikooli 17–103, 51005 Tartu
  • Marketing and Communication Office
    Faculty phone: 
    +372 737 5687
    Faculty address: 
    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
  • Office of Academic Affairs
    Faculty phone: 
    +372 737 5620
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
    Faculty phone: 
    +372 737 6632
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
    Faculty phone: 
    +372 737 5600
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Student Council
    Faculty phone: 
    +372 737 5400
    Faculty address: 
    Ülikooli 18b, 51005 Tartu
Other Units
  • University of Tartu Academic Sports Club
    Faculty phone: 
    +372 737 5371
    Faculty address: 
    Ujula 4, 51008 Tartu
  • Tartu Student Village
    Faculty phone: 
    +372 740 9959
    Faculty address: 
    Narva mnt 25, 51013 Tartu
  • Tartu Students’ Club
    Faculty phone: 
    +372 730 2400
    Faculty address: 
    Kalevi 24, 51010 Tartu
  • University of Tartu Press
    Faculty phone: 
    +372 737 5945
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Tartu University Hospital
    Faculty address: 
    L. Puusepa 1a, 50406 Tartu
  • University of Tartu Foundation
    Faculty phone: 
    +372 737 5852
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • View all other units

Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    Lossi 3, 51003 Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
    Faculty address: 
    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
Faculty address: 
Lossi 36, 51003 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
    +372 737 6440
    Faculty address: 
    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
    Faculty phone: 
    +372 737 5582
    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
    Faculty phone: 
    +372 737 6310
    Faculty address: 
    J. Liivi 4, 50409 Tartu
  • Institute of Psychology
    Faculty phone: 
    +372 737 5902
    Faculty address: 
    Näituse 2, 50409 Tartu
  • School of Law
    Faculty phone: 
    +372 737 5390
    Faculty address: 
    Näituse 20–324, 50409 Tartu
  • Institute of Social Studies
    Faculty phone: 
    +372 737 5188
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Narva College
    Faculty phone: 
    +372 740 1900
    Faculty address: 
    Raekoja plats 2, 20307 Narva
  • Pärnu College
    Faculty phone: 
    +372 445 0520
    Faculty address: 
    Ringi 35, 80012 Pärnu
Faculty of Medicine
Faculty phone: 
+372 737 5326
Faculty address: 
Ravila 19, 50411 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5326
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Biomedicine and Translational Medicine
    Faculty phone: 
    +372 737 4210
    Faculty address: 
    Biomeedikum, Ravila 19, 50411 Tartu
  • Institute of Pharmacy
    Faculty phone: 
    +372 737 5286
    Faculty address: 
    Nooruse 1, 50411 Tartu
  • Institute of Dentistry
    Faculty phone: 
    +372 731 9856
    Faculty address: 
    Raekoja plats 6, 51003 Tartu
  • Institute of Clinical Medicine
    Faculty phone: 
    +372 737 5323
    Faculty address: 
    L. Puusepa 8, 50406 Tartu
  • Institute of Family Medicine and Public Health
    Faculty phone: 
    +372 737 4190
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
    Faculty phone: 
    +372 737 5360
    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
Faculty phone: 
+372 737 5820
Faculty address: 
Vanemuise 46–208, 51014 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5820
    Faculty address: 
    Vanemuise 46–208, 51005 Tartu
  • Institute of Computer Science
    Faculty phone: 
    +372 737 5445
    Faculty address: 
    J. Liivi 2, 50409 Tartu
  • Estonian Marine Institute
    Faculty phone: 
    +372 671 8902
    Faculty address: 
    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
    Faculty phone: 
    +372 737 5261
    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Mathematics and Statistics
    Faculty phone: 
    +372 737 5860
    Faculty address: 
    J. Liivi 2, 50409 Tartu
  • Institute of Molecular and Cell Biology
    Faculty phone: 
    +372 737 5011
    Faculty address: 
    Riia 23, 23b–134, 51010 Tartu
  • Tartu Observatory
    Faculty phone: 
    +372 737 4510
    Faculty address: 
    Observatooriumi 1, Tõravere, 61602 Tartumaa
  • Institute of Technology
    Faculty phone: 
    +372 737 4800
    Faculty address: 
    Nooruse 1, 50411 Tartu
  • Institute of Ecology and Earth Sciences
    Faculty phone: 
    +372 737 5835
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Institutions
  • Library
    Faculty phone: 
    +372 737 5702
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
    Faculty phone: 
    +372 737 5581
    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Institute of Genomics
    Faculty phone: 
    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Museum
    Faculty phone: 
    +372 737 5674
    Faculty address: 
    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
    Faculty phone: 
    +372 737 6076
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
  • Administrative Office
    Faculty phone: 
    +372 737 5606
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Centre for Entrepreneurship and Innovation
    Faculty phone: 
    +372 737 6339
    Faculty address: 
    Lossi 3, III floor, 51003 Tartu
  • University Office in Tallinn
    Faculty phone: 
    +372 737 6600
    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
    Faculty phone: 
    +372 737 5137
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
    Faculty phone: 
    +372 737 5125
    Faculty address: 
    Jakobi 4, 51005 Tartu
  • Grant Office
    Faculty phone: 
    +372 737 6215
    Faculty address: 
    Lossi 3, III floor, 51003 Tartu
  • Information Technology Office
    Faculty phone: 
    +372 737 6000, IT-help: +372 737 5500
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Human Resources Office
    Faculty phone: 
    +372 737 5145
    Faculty address: 
    Ülikooli 18, rooms 302 and 304, 50090 Tartu
  • Internal Audit Office
    Faculty address: 
    Ülikooli 17–103, 51005 Tartu
  • Marketing and Communication Office
    Faculty phone: 
    +372 737 5687
    Faculty address: 
    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
  • Office of Academic Affairs
    Faculty phone: 
    +372 737 5620
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
    Faculty phone: 
    +372 737 6632
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
    Faculty phone: 
    +372 737 5600
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Student Council
    Faculty phone: 
    +372 737 5400
    Faculty address: 
    Ülikooli 18b, 51005 Tartu
Other Units
  • University of Tartu Academic Sports Club
    Faculty phone: 
    +372 737 5371
    Faculty address: 
    Ujula 4, 51008 Tartu
  • Tartu Student Village
    Faculty phone: 
    +372 740 9959
    Faculty address: 
    Narva mnt 25, 51013 Tartu
  • Tartu Students’ Club
    Faculty phone: 
    +372 730 2400
    Faculty address: 
    Kalevi 24, 51010 Tartu
  • University of Tartu Press
    Faculty phone: 
    +372 737 5945
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Tartu University Hospital
    Faculty address: 
    L. Puusepa 1a, 50406 Tartu
  • University of Tartu Foundation
    Faculty phone: 
    +372 737 5852
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • View all other units

Research areas

Our main research areas are the pathogenesis of musculoskeletal diseases, chronic inflammatory diseases and degenerative diseases. We focus on the bioenergetic and pathophysiological studies of heart failure and age-related sarcopenia. We study interaction mechanisms of glycolysis and oxidative phosphorylation and functional complexes of mitochondria with ATPases. Our research aims to describe changes in these processes across different pathophysiological conditions (atrial dilatation, inflammation, ER stress). The specific impact of altered cellular bioenergetics in the pathogenesis of sarcopenia and the relationship between energy metabolism, expression of differentiation markers and activation of signalling systems are under investigation.

Previous research has studied the alterations in the regulation of oxidative phosphorylation by extramitochondrial calcium in brain cells and changes in the crosstalk between oxidative phosphorylation and glycolysis in the pathogenesis of cardiac and skeletal muscle disorders (cardiac failure and sarcopenia). In addition, the role of some signalling pathways (HIF-1alpha, PKB/Akt) and metabolic substrates (creatine) in cellular damage during heart failure and sarcopenia has been studied. We have found that aged skeletal muscles have reduced regenerative potential combined with disturbed energy metabolism, which increases vulnerability of myoblasts to hypoxia and calcium overload. In our research program we combine systems genetics with more focused studies on cellular bioenergetics and ER stress. Ongoing projects include the following:
- Energy metabolism in cardiac and skeletal muscle and in the brain during heart failure, neurodegenerative diseases and aging;
- Role of genetic factors in the pathogenesis of bone and joint diseases (osteoporosis, osteoarthritis,Ostegenesis Imperfecta, etc);
- Genetic studies of rare diseases;
- Discovery and description of new genetic factors in the pathogenesis of psoriasis;
- Genetic architecture of Parkinson's disease (PD), the role of genetic factors in the pathogeneisis of PD;
- The genetics of athletic performance and sports injuries;
- Biobank and disease collections to advance the studies on pathophysiology of diseases.

Department of Pathophysiology has expertise in cellular energy metabolism, disease models, genomics (genome and exome sequencing, RNAseq, genotyping), human studies, biobanking and complex data analysis.

Figure 1. Translational studies on bone and muscle pathologies include different disorders, different target tissues and combine four different approaches.

 

Projects

IUT20-46  01.01.2014–31.12.2019
Translational studies on bone and muscle pathologies
Principal investigator: Sulev Kõks
Diseases of muscles and bones are one of the largest groups of clinical disorders and have significant impact on disease burden for society. These disorders are highly prevalent in elderly people and have significant impact for societies with aging population. Despite their high prevalence, the pathophysiology behind these disorders is not well understood and for many conditions neither existing therapies nor prophylaxis are completely efficacious. Better understanding about the pathophysiology and a translational approach are needed. The general goal of our research is to describe novel pathogenetic pathways (energy metabolism, endoplasmic reticulum (ER) stress) and to discover gene networks for these disorders. Currently ongoing activities include cellular bioenergetics on aging muscle and heart. We also analyze diseased bones and joints (osteoporosis, osteoarthritis). For these research activities, we combine systems genetics analysis with more focused studies on cellular bioenergetics and ER stress.

European Commission 7-th Framework Programme Project MARTO13136R 01.08.2013–31.07.2018 www.hyporth.eu
HypOrth - New approaches in the development of Hypoallergenic implant material in Orthopedics: steps to personalised medicine
Principal investigator: Aare Märtson, Sulev Kõks
Due to increasing life span of human beings in industrialized countries the diagnosis of osteoarthritis is the most common indication for implantation of artificial joints. The implantation of total hip (THA) and total knee arthroplasties (TKA) is based on 50 years of experience and is one of the most successful and most common treatments for osteoarthritis of the joint. Although the clinical outcome of total joint arthroplasty is usually excellent, some implants become loose and require re-implantation. Re-implantation surgery is more complex than primary joint replacement, takes longer to perform, implants are more expensive and the patient`s hospital stay is prolonged, incurring higher costs. To date,  there are no predictive measures or indicative markers for an adverse immune reaction (AIR) to implant material exist, since results of patch tests of skin for allergy do not correlate with the risk for implant hypersensitivity. In addition, no clear strategic diagnostic methods have been found to differentiate prosthetic loosening caused by AIR from a low-grade infection. The materials used for artificial prosthesis by default are Titanium (TiAl6V4, TiAl6Nb7 – forged alloy), CoCrMo (forged alloy), ceramics and UHMWPE (Ultra High Molecular Weight PolyEthylene). Despite application of different biocompatible materials, the ultimate material with properties of native joints has not been found to date. This project provides a comprehensive view on the problem of adverse immune reactions to implant material including immunological, genomic, reverse engineering, microbiological, epidemiological and clinical aspects. The ultimate goals of our project are to develop a novel orthopaedic implant prototype based on hypoallergenic materials and to define individual predictive and general diagnostic biomarkers for AIR.

Estonian Science Foundation Project ETF8736 01.01.2011-31.12.2014
Cellular energetic depression: basis of cardiac and skeletal muscle disorders and target of protective mechanisms.
Principal investigator: Enn Seppet/Margus Eimre (margus.eimre [ät] ut.ee)
Research staff: Kalju Paju, Ehte Orlova, Margus Eimre, Lumme Kadaja, Arno Ruusalepp, Andres Piirsoo, Tatjana Kums, Helena Gapeyeva, Mati Pääsuke, Taavi Põdramägi, Mart Roosimaa, Reedik Pääsuke
This project addresses several interrelated aspects of the role of impaired energy metabolism in the pathogenesis of disorders of muscle cells, such as (i) alterations in regulation of oxidative phosphorylation (OXPHOS) by extramitochondrial Ca2+ and (ii) changes in cross-talk between OXPHOS and glycolysis in conditions of hypoxia, cardiac failure and aging related sarcopenia. (iii) The potential of some signalling pathways (HIF-1alpha, p38, MEK/Erk, and PKB/Akt) in protection against cardiac disease and combating sarcopenia will be tested.

Figure 2. Disorders of mitochondrial ATP synthesis and energy transfer cause cellular energy depression (CED) and lead to reduced ability of muscle to work. The resulting reactive oxygen species formation and Ca2+overload further impair the mitochondria and energy transfer leading to cell death. CK – creatine kinase isoenzymes involved in energy transfer, AK – adenylate kinase, PK – pyruvate kinase, HK II – isoenzyme of hexokinase, which may in conditions of energy deficit, be bound to mitochondria as an adaptation mechanism promoting cellular energy supply. MOMP- mitochondrial outer membrane permeabilization, PT – permeability transition of mitochondrial inner membraane, Inhibitors – proteins of Bcl family and  cyclosporine A, which prevent the formation of channels in the membranes of mitochondria, Aralar – aspartate/glutamate carrier, component of malate-aspartate  shuttle, R.C. – respiratory chain.

LARFS12124T 01.05.2012–31.08.2015
Estonia-Vietnam collaboration in medical science
Principal investigator: Sulev Kõks
The aim of the DIOXMED initiative is to create a foundation for international research collaboration between universities and clinics in Estonia, the UK and Vietnam in order to increase awareness of the effects of dioxins as the cause of increasing environmental pollution problems in people’s everyday lives (developmental disorders, infertility and others), in veterinary research and the environment. In the framework of this project international research collaboration will be developed with Estonian medical researchers to raise international competitiveness in the fields of bone and joint disease and reproductive medicine among Vietnamese researchers with great research potential. Active cooperation will be developed for initiating new research projects in Vietnam’s medical education and research institutes (Hue University of Medicine and Pharmacy), Vietnamese hospitals (in Hue, Da Nang, Saigon, Hanoi), the Vietnamese Genetic Consultation and Disabled Children’s Centre and King’s College in London.

International collaboration to develop regenerative medicine (REMARK) 01.05.2012–31.08.2015
Principal investigator: Eric Tkaczyk
REMARK is a regenerative medicine grant from the Estonian Ministry of Education and Research to fund international research collaboration and the exchange of students and scientists. Domestic partners include the University of Tartu (including the Estonian Genome Center with DNA samples of 5% of the country's population), Estonian Life Sciences University. International partners include the Regenerative Medicine Coalition and Vanderbilt University. The main areas of collaboration are:
1) innovative three-dimensional cell cultures and methods from materials science;
2) non-invasive advanced imaging and optical methods;
3) biobanking, genomics and proteomics

European Commission 7-th Framework Programme Project MARMP09022R 01.01.2009-31.12.2012
MYOAGE- Understanding and combating age related muscle weakness.
Principal investigator: Enn Seppet/ Mati Pääsuke
Kalju Paju, Lumme Kadaja, Margus Eimre, Nadežda Peet, Merike Kruus, Jelena Sokk, Reedik Pääsuke, Mart Roosimaa, Helena Gapeyeva, Jaan Ereline, Tatjana Kums, Herje Aibast, Aare Märtson, Andres Piirsoo, AnuKõiveer, Tauno Koovit.
The age related changes in functions of the mitochondrial respiratory chain complexes and functional coupling of mitochondrial kinases to oxidative phosphorylation and peripheral kinases to ATPases in relation to mitochondrial capacity to accumulate Ca2+, expression of kinases, uncoupler proteins and contractile function are being studied. The relationships between the changes of energy metabolism, expression of differentiation markers and activation of signaling pathways will be tested in primary myoblasts cultured from biopsy samples of m. quadriceps. Alterations in regulation of oxidative phosphorylation by extramitochondrial Ca2+ (via glutamate-aspartate transporter: aralar system) are being studied. The role of pro- and anti-inflammatory cytokines in modulating the energy metabolism is being assessed. Genomic analyses of mitochondrial and cytoskeletal proteins in myocytes in different steps of myogenesis are being performed.

Targeted Financing Project SF0180114As08 01.01.2008-31.12.2013
Role of impaired oxidative phosphorylation and compartmentation of energy metabolism in pathophysiology of diseased and aged muscle cells.
Principal investigator: Enn Seppet/Lumme Kadaja
Research staff: Margus Eimre, Lumme Kadaja, Ehte Orlova, Kalju Paju, Arno Ruusalepp, Evelin Seppet
The aim of the project is to assess the function of the systems of energy metabolism (oxidative phosphorylation and energy transfer) in cardiac and skeletal muscle cells in conditions of heart failure, neurodegenerative diseases and ageing. The functions of the mitochondrial respiratory chain complexes and functional couplings of mitochondrial kinases to oxidative phosphorylation and peripheral kinases to ATPases in relation to mitochondrial capacity to accumulate Ca2+, expression of kinases, cytoskeletal proteins, uncoupler proteins and contractile function will be studied. In studies of ageing muscles, special attention is played to the roles of mTOR- and AMPK-mediated pathways and pro- and antiinflammatory cytokines in modulating the intracellular energy.

Estonian Science Foundation Project ETF7823 01.01.2009-31.12.2012
Dynamics of formation modular bioenergetic systems during differentiation of stem cells into myocytes and their degradation during ageing.
Principal investigator: Valdur Saks
Research staff: Toomas Tiivel, Anu Nutt, Kairi Tammoja, Kersti Tepp, Tuuli Käämbre, Peeter Sikk, Madis Metsis, Natalja Timohhin, Andres Piirsoo, Ehte Orlova, Enn Seppet, Kalju Paju, Lumme Kadaja, Karin Tamm, Minna Karu, Tiina Drell, Igor Ševtšuk, Vladimir Tšekulaje, Aleksandr Klepinin
Genomic and proteomic analyses of mitochondrial and cytoskeletal proteins in myocytes and stem cells in different steps of myogenesis are being performed.

 

Main publications

  1. Roosimaa M, Põdramägi T, Kadaja L, Ruusalepp A, Paju K, Puhke R, Eimre M, Orlova E, Piirsoo A, Peet N, Gellerich FN, Seppet E (2013). Dilation of human atria: Increased diffusion restrictions for ADP, overexpression of hexokinase 2 and its coupling to oxidative phosphorylation in cardiomyocytes.Mitochondrion. 13: 399-409.
  2. Kõks S, Overall RW, Ivask M, Soomets U, Guha M, Vasar E,  Fernandes C, Schalkwyk LC (2013).Silencing of the WFS1 gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage. Physiological genomics. 45: 182-190.
  3. Seppet E, Orlova E, Seene T, Gellerich FN (2012). Adaptation of cardiac and skeletal muscle mitochondria to endurance training: implications for cardiac protection. Ostadal B, Dhalla N.S (Toim.). Cardiac Adaptations (375–402). Springer.
  4. Ellinghaus D, Ellinghaus E, Nair RP, Stuart PE, Esko T, Metspalu A, Debrus S, Raelson JV, Tejasvi T, Belouchi M, West SL, Barker JN, Kõks S, Kingo K, Balschun T, Palmieri O, Annese V, Gieger C, Wichmann HE, Kabesch M, Trembath RC, Mathew CG, Abecasis GR, Weidinger S, Nikolaus S, Schreiber S, Elder JT, Weichenthal M, Nothnagel M, Franke A (2012). Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis Identifies Seven Shared Susceptibility Loci. American Journal of Human Genetics. 6: 636-647.
  5. Gellerich FN, Gizatullina Z, Trumbekaite S, Korzeniewski B, Gaynutdinov T, Seppet E, Vielhaber S, Heinze HJ, Striggow F (2012). Cytosolic Ca2+ regulates the energization of isolated brain mitochondria by formation of pyruvate through the malate-aspartate shuttle. Biochem J. 443: 747–755.
  6. Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J, Duffin KC, Helms C, Goldgar D, Li Y, Paschall J, Malloy MJ, Pullinger CR, Kane JP, Gardner J, Perlmutter A, Miner A, Feng BJ, Hiremagalore R, Ike RW, Christophers E, Henseler T, Ruether A, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok P, Menter A, Lathrop GM, Wise C, Begovich AB, Genetic Analysis of Psoriasis Consortium; Onoufriadis A, Weale ME, Hofer A, Salmhofer W, Wolf P, Kainu K, Saarialho-Kere U, Suomela S, Badorf P, Hüffmeier U, Kurrat W, Küster W, Lascorz J, Mössner R, Schürmeier-Horst F, Ständer M, Traupe H, Bergboer JG, Heijer Md, van de Kerkhof PC, Zeeuwen PL, Barnes L, Campbell LE, Cusack C, Coleman C, Conroy J, Ennis S, Fitzgerald O, Gallagher P, Irvine AD, Kirby B, Markham T, McLean WH, McPartlin J, Rogers SF, Ryan AW, Zawirska A, Giardina E, Lepre T, Perricone C, Martín-Ezquerra G, Pujol RM, Riveira-Munoz E, Inerot A, Naluai AT, Mallbris L, Wolk K, Leman J, Barton A, Warren RB, Young HS, Ricano-Ponce I, Trynka G, Pellett FJ, Henschel A, Aurand M, Bebo B, Gieger C, Illig T, Moebus S, Jöckel KH, Erbel R, Wellcome Trust Case Control Consortium 2; Donnelly P, Peltonen L, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Duncanson A, Jankowski J, Markus HS, Mathew CG, McCarthy MI, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Samani N, Viswanathan AC, Wood NW, Bellenguez C, Freeman C, Hellenthal G, Giannoulatou E, Pirinen M, Su Z, Hunt SE, Gwilliam R, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Perez ML, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC (2012). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature Genetics. 44: 1341-1348.
  7. Kadaja L, Eimre M, Paju K, Roosimaa M, Põdramägi T, Kaasik P, Pehme A, Orlova E, Mudist M, Peet N, Piirsoo A, Seene T, Gellerich FN, Seppet EK (2010). Impaired oxidative phosphorylation in overtrained rat myocardium. Experimental and Clinical Cardiology. 15: e116-e127.
  8. Saks V, Guzun R, Timohhina N, Tepp K, Varikmaa M. Monge C, Beraud N, Käämbre T, Kuznetsov A, Kadaja L, Eimre M, Seppet E (2010). Structure - function relationships in feedback regulation of energy fluxes in vivo in health and disease: Mitochondrial Interactosome. Biochimica et Biophysica Acta. 1797: 678-697.