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valdkonna dekanaat

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valdkonna dekanaat

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Asutused

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Tugiüksused

ettevõtlus- ja innovatsioonikeskus

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Muud üksused

MTÜ Tartu Ülikooli Akadeemiline Spordiklubi

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MTÜ Tartu Üliõpilasküla

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SA Tartu Ülikooli Kliinikum

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Tartu Ülikooli Sihtasutus

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Vaata kõiki muid üksusi

Publikatsioonid ja patendid

Publikatsioonid (viimased 5 aastat)

Tootsi, K, Märtson, A, Zilmer, M, Paapstel, K, Kals, J (2016). Increased arterial stiffness in patients with end-stage osteoarthritis: a case-control study. BMC Musculoskeletal Disorders. doi: 10.1186/s12891-016-1201-x.
Kriisa, K, Haring, L, Vasar, E, Koido, K, Janno, S, Vasar, V, Zilmer, K, Zilmer, M (2016). Antipsychotic Treatment Reduces Indices of Oxidative Stress in First-Episode Psychosis Patients. Oxid Med Cell Longev. http://dx.doi.org/10.1155/2016/9616593.
Paapstel, K, Zilmer, M, Eha, J, Tootsi, K, Piir, A, Kals, J (2016). Early biomarkers of renal damage in relation to arterial stiffness and inflammation in male coronary arter disease patients. Kidney Blood Pressure Res. 41: 488-497.
Tootsi, K, Kals, J, Zilmer, M, Paapstel, K, Märtson, A (2016). Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness. Int J Rheumatology. http://dx.doi.org/10.1155/2016/6402963
Paapstel, K, Kals, J, Eha, J, Tootsi, K, Ottas, A, Zilmer, M (2016). Metabolomic profile of lipid metabolism, arterial stiffness and hemodynamics in male coronary artery disease patients. IJC Metabolic & Endocine. 11: 13-18.
Koido, K, Innos, J, Haring, L, Zilmer, M, Ottas, A, Vasar, E (2016). Taurine and Epidermal Growth Factor Belong to the Signature of First-Episode Psychosis. Frontiers in Neuroscience. doi: 10.3389/fnins.2016.00331
Zagura, M, Kals, J, Paapstel, K, Serg, M, Kampus, P, Eha, J, Zilmer, M (2016). Response to Aboyans, et al.: Estimation of pulse wave velocity in patients with peripheral artery disease: a word of caution. Hypertens Res. Apr 14. doi: 10.1038/hr.2016.34. [Epub ahead of print]
Paapstel, K, Zilmer, M, Eha,J, Tootsi, K, Piir, A, Kals, J (2016). Association Between Fibulin-1 and Aortic Augmentation Index in Male Patients with Peripheral Arterial Disease. Eur J Vasc Endovasc Surg. 51: 76-82.
Haring, L, Koido, K, Vasar, V, Leping, V, Zilmer, K, Zilmer, M, Vasar E (2015). Antipsychotic treatment reduces psychotic symptoms and markers of low-grade inflammation in first episode psychosis patients, but increases their body mass index. Schizophr Res. Sep 10. pii: S0920-9964(15)00456-9. doi: 10.1016/j.schres.2015.08.027.
Ilisson, J, Zagura, M, Zilmer, K, Salum, E, Heilman, K, Piir, A, Tillmann, V, Kals, J, Zilmer, M, Pruunsild C (2015). Increased carotid artery intima-media thickness and myeloperoxidase level in children with newly diagnosed juvenile idiopathic arthritis. Arthritis Res Ther. Jul 16;17:180. doi: 10.1186/s13075-015-0699-x.
Zagura, M, Kals, J, Kilk, K, Serg, M, Kampus, P, Eha, J, Soomets, U, Zilmer, M (2015). Metabolomic signature of arterial stiffness in male patients with peripheral arterial disease. Hypertens Res. Jul 2. doi: 10.1038/hr.2015.71. [Epub ahead of print].
Rehema, A, Kullisaar, T, Seer, K, Reinmann, K, Zilmer, M, Kilk, K (2015). Proteomic proof that a probiotic elevates glutathione level in human seerum. Open Life Sci. 10: 193-200
Sütt, S, Altpere, A, Reimets, R, Visnapuu, T, Loomets, M, Raud, S, Salum, T, Mahlapuu, R, Kairane, C, Zilmer, M, Vasar, E (2015). Wfs1-deficient animals have brain-region-specific changes of Na+ ,K+ -ATPase activity and mRNA expression of α1 and β1 subunits. J Neurosci Res. 93: 530-537. doi: 10.1002/jnr.23508. Epub 2014 Nov 10.
Ganna, A, Salihovic, S, Sundstrom, J, Broeckling, CD, Hedman, AK, Magnusson, PKE, Pedersen, NL, Larsson. A, Siegbahn, A, Zilmer, M, Prenni, J, Ärlöv, J, Lind, L, Fall, T, Ingelsson, E (2014). Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease. Plos Genetic. 10(12): e1004801. doi:10.1371/journal.pgen.1004801.
Herbert, A, coauthors (2014). Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors. European Heart J. doi:10.1093/eurheartj/ehu293.
Serg, M, Graggaber, J, Kampus, P, Zagura, M, Kals, J, Mäki-Petaja, K, Cheriyan, J, Zilmer, M, Eha, J, Jm McEnie¬ry, C. M, Wilkinson, I.B (2014). Value of haemodynamic profiling to the response of antihypertensive therapy. Artery Res. 8: 189-196.
Kaur, S, Zilmer, K, Leping, V, Zilmer, M (2014). Allergic contact dermatitis is associated with significant oxidative stress. Dermatol Res Pract. doi: 10.1155/2014/415638. Epub 2014 Aug 11.
Kals, J, Lieberg, J, Kampus, P, Zagura, M, Eha, J, Zilmer M (2014). Prognostic Impact of Arterial Stiffness in Patients with Symptomatic Peripheral Arterial Disease. Eur J Vasc Endovasc Surg. Jun 21. pii: S1078-5884(14)00272-X. doi: 10.1016/j.ejvs.2014.05.018. [Epub ahead of print]
Salum, E, Butlin, M, Kals, J, Zilmer, M, Eha J, Avolio, A.P, Arend, A, Aunapuu, M, Kampus, P (2014). Angiotensin II receptor blocker telmisartan attenuates aortic stiffening and remodelling in STZ-diabetic rats. Diabetol Metab Syndr. May 20;6:57. doi: 10.1186/1758-5996-6-57.
Kaldur, T, Kals, J, Ööpik, V, Zilmer, M, Zilmer, K, Eha, J, Unt, E (2014). Effects of heat acclimation on changes in oxidative stress and inflammation caused by endurance capacity test in the heat. Oxid Med Cell Longev. doi: 10.1155/2014/107137. Epub 2014 May 11.
Kals, J, Lieberg, J, Kampus, P, Zagura, M, Eha, J, Zilmer M (2014). Prognostic impact of arterial stiffness in patients with symptomatic peripheral arterial disease. Eur J Vasc Endovasc Surg. 48: 308-315.
Kairane, C, Mahlapuu, R, Ehrlich, K, Zilmer, M, Soomets, U (2014). The Effects of Different Antioxidants on the Activity of Cerebrocortical MnSOD and Na,K-ATPase from post mortem Alzheimer’s Disease and Age-matched Normal Brains. Alzheimer Res. 11: 79-85.
Kaur, S, Zilmer, K, Leping, V, Zilmer, M (2013). Serum methylglyoxal level and its association with oxidative stress and disease severity in patients with psoriasis. Arch Dermatol Res. 305: 489-494.
Kaldur, T, Kals, J, Oöpik, V, Burk, A, Kampus, P, Zagura, M, Zilmer, M, Unt, E (2013). Heat acclimation increases arterial elasticity in young men. Appl Physiol Nutr Metab. 38: 922-927.
Gustafsson, S, Lind, L, Söderberg, S, Zilmer, M, Hulthe, J, Ingelsson, E (2013). Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin. Obesity. 21: 1467-1473.
Salum, E, Kals, J, Kampus, P, Salum, T, Zilmer, K, Aunapuu, M, Arend, A, Eha, J, Zilmer, M (2013). Vitamin D reduces deposition of advanced glycation end-products in the aortic wall and systemic oxidative stress in diabetic rats. Diabetes Res Clin Pract. 100: 243-249.
Utsal, L, Tillmann, V, Zilmer, M, Mäestu, J, Purge, P, Saar, M, Lätt, E, Maasalu, K, Jürimäe, T, Jürimäe, J (2013). Negative correlation between serum IL-6 level and cardiorespiratory fitness in 10- to 11-year-old boys with increased BMI. J Pediatr Endocrinol Metab. 18: 1-6.
Kullisaar, T, Türk, S, Punab, M, Veskioja, A, Songisepp, E, Zilmer, K, Zilmer, M (2013). Dietary modification of lower urinary tract symptoms with fermented whey product. Open J Urology. 3: 114-120.
Velthut, A, Zilmer, M, Zilmer, K, Kaart, T, Karro, H, Salumets, A (2013). Elevated blood plasma antioxidant status is favourable for achievieng IVF/ICFI pregnancy. Reproductive Biomedicine Online. 26: 345-352.
Zagura, M, Kals, J, Serg, M, Kampus, P, Zilmer, M, Jakobson, M, Unt, E, Lieberg, J, Eha, J (2012). Structural and biochemical characteristics of arterial stiffness in patients with atherosclerosis and in healthy subjects. Hypertens Res. 35: 1032-1037.
Salum, E, Kampus, P, Zilmer, M, Eha, J, Butlin, M, Avolio, AP, Põdramägi, T, Arend, A, Aunapuu, M, Kals, J (2012). Cardiovasc Diabetol. Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes. Cardiovasc Diabetol. 11: 58.
Kairane, C, Mahlapuu, R, Ehrlich, K, Kilk, K, Zilmer, M, Soomets, U (2012). Diverse effects of glutathione and UPF peptides on antioxidant defense system in human erythroleukemia cells K562. Int J Peptides. 2012: 124163.
Raukas, M, Rebane, R, Mahlapuu, R, Jefremov, V, Zilmer, K, Karelson, E, Bogdanovic, N, Zilmer, M (2012). Mitochondrial oxidative stress index, activity of redox-sensitive aconitase and effects of endogenous anti- and pro-oxidants on its activity in control, Alzheimer's disease and Swedish Familial Alzheimer's disease brain. Free Rad Res. 46: 1490-1495.
Kaur, S, Zilmer, K, Leping, V, Zilmer, M (2012). Comparative study of systemic inflammatory responses in psoriasis vulgaris and mild/moderate allergic contact dermatitis. Dermatology. 225: 54-61.
Serg, M, Kampus, P, Kals, J, Zagura, M, Zilmer, M, Zilmer, K, Kullisaar, T, Eha, J (2012). Nebivolol and metoprolol: long-term effects on inflammation and oxidative stress in essential hypertension. Scand J Clin Lab Invest. 72: 427-432.
Utsal, L, Tillmann, V, Zilmer, M, Mäestu, J, Purge, P, Jürimäe, J, Saar, M, Lätt, E, Maasalu, K, Jürimäe, T (2012). Elevated Serum IL-6, IL-8, MCP-1, CRP, and IFN-γ Levels in 10- to 11-Year-Old Boys with Increased BMI. Horm Res Paediatr. 23: 31-39.
Kaldmae, M, Salum, E, Annuk, M, Kals, J, Kampus, P, Zilmer, K, Eha, J, Zilmer, M (2012). Oxidative stress status in homeless people. Oxid Antioxid Med Sci. 1: 35-39.
Zagura, M, Serg, M, Kampus, P, Zilmer, M, Eha, J, Unt, E, Lieberg, J, Cockroft, J, Kals, J (2011). Aortic stiffness and vitamin D are independent markers of aortic calcification in patients with peripheral arterial disease and in healthy subjects. Eur J Vasc Endovasc Surg. 42: 689-695.
Kampus, P, Serg, M, Kals, J, Zagura, M, Muda, P, Karu, K, Zilmer, M, Eha, J (2011). Differential Effects of Nebivolol and Metoprolol on Central Aortic Pressure and Left Ventricular Wall Thickness. Hypertension. 57: 1122-1128.
Kaur, S, Zilmer, K, Leping, V, Zilmer, M (2011). The levels of adiponectin and leptin and their relation to other markers of cardiovascular risk in patients with psoriasis. J Eur Acad Dermatol Venereol. 25: 1328-1333.
Kaldmäe, M, Zilmer, M, Viigimaa, M, Zemtsoskaja, G, Tomberg, K, Kaart, T, Annuk, M (2011). Cardiovascular risk factors in homeless people. Ups J Med Sci. 116: 200-207.
Kals, J, Zagura, M, Serg, M, Kampus, P, Zilmer, K, Unt, E, Lieberg, J, Eha, J, Peetsalu, A, Zilmer, M (2011). β2-microglobulin, a novel biomarker of peripheral arterial disease, independently predicts aortic stiffness in these patients. Scand J Clin Lab Invest. 71: 257-263.
Salum, E, Zilmer, M, Kampus, P, Kals, J, Unt, E, Serg, M, Zagura, M, Blöndal, M, Zilmer, K, Eha J (2011). Effects of a long-term military mission on arterial stiffness, inflam-mation markers, and vitamin D level. Int J Cardiol. 151: 106-107.
Serg, M, Kampus, P, Kals, J, Zagura, M, Muda, P, Toumainen, TP, Zilmer, K, Salum, E, Zilmer, M, Eha, J (2011). Association between asymmetric dimethylarginine and indices of vascular function in patients with essential hypertension. Blood Press. 20: 111-116.
Kullisaar, T, Shepetova, J, Zilmer, K, Songisepp, E, Rehema, A, Mikelsaar, M, Zilmer, M (2011). An antioxidant probiotic reduces postprandial lipemia and oxidative stress. CEJB. 6: 32-40.

Patendid:

Estonian Patent nr 05721 (19.08.2014). Isolee¬ritud mikro¬orga¬nis¬mide tüved Lactoba¬cillus plantarum MCC1 DSM 23881 ja selle kasutamine. T.Kullisaar , M. Zilmer, E. Tammsaar, A. Veski¬oja, E. Songisepp, K. Zilmer, L. Bobrovski, K. Ehrlich, M. Rät¬sep, M. Punab, M. Vasar, M. Mikelsaar.
Patent of Russian Federation no 2486234. Isolated microorganism strain Lactobacillus plantarum INDUCIA DSM 21379 as a probiotic enhancing natural immunity, product and composition comprising said microorganism and use of said microorganism for medicinal preparation enhancing cellular immunity. M. Mikelsaar, E. Songisepp, I. Scmidt, J. Shepetova, P. Hütt, M. Zilmer, K. Truusalu, K. Kilk.
Patent of Russian Federation no 2477750. Isolated microorganism strain Lactobacillus plantarum TENSIA DSM 21380 as antimicrobial and antihypertensive probiotic, food poducts and composition comprising said microorganism and use of said microorganism for preparation of antihypertensive medicine and method for suppressing pathogens and non-starter lactobacilli in food product. E. Songisepp, M. Mikelsaar, M. Rätsep, M. Zilmer, P. Hütt, M. Utt, M. K. Zilmer, J. Üksti, S. Kõljalg.
Estonian patent EE 04580 (15.02.2006). Mikroorganismi tüvi Lactobacillus fermentum ME-3 kui antimikroobne ja antioksüdantne probiootikum, Microorganism strain L. Fermentum ME-3 as a novel antimicrobial and antioxidative probiotic. M. Mikelsaar, M. Zilmer, T. Kullisaar, H. Annuk, E.Songisepp.
Patent of Russian Federation No RU 2284354 (26.09,2006). Probiotik, M. Mikelsaar, M. Zilmer, T. Kullissaar, H. Annuk, E.Songisepp.
U.S. Patent No. 7244424 (17.07.2007). Strain of microrganism Lactobacillus fermentum ME-3 as a novel antimicrobial and antioxidative probiotic. M. Mikelsaar, M. Zilmer, T. Kullisaar, H. Annuk, E. Songisepp.
Estonian Patent No 05340 (13.05.2008). Isoleeritud mikroorganismi tüvi Lactobacillus plantarum Tensia DSM 21380 ja selle kasutamine antimikroobse ja vererõhku alandava probiootikumina ning ravimi valmistamiseks ning toiduaine realiseerimisaja pikendamiseks ja toiduaines kontamineerivate mikroorganismide allasurumiseks, tüve sisaldav toiduaine ja kompositsioon. E.Songisepp, M. Mikelsaar, M. Rätsep, M. Zilmer, P. Hütt, M. Utt, K. Zilmer, J. Üksti, S. Kõljalg.
Estonian Patent No 05341 (13.05.2008). Isoleeritud mikroorganismi tüvi Lactobacillus plantarum INDUCIA DSM 21379 kui organism loomulikku kaitsevõimat tõstev probiootik, seda sisaldav toiduaine ja kompositsioon ning mikroorganismi kasutamine rakulist immuunsust tõstva ravimi valmistamiseks. M. Mikelsaar, E. Songisepp, I. Smidt, J. Stsepetova, P. Hütt, M. Zilmer, K. Truusalu, K.Kilk.
European Patent EP1401457B1 (01.12.2010). Strain of micro-organism Lactobacillus fermentum ME-3 as novel antioxidative probiotic., M. Mikelsaar, M. Zilmer, T. Kullissaar, H. Annuk, E. Songisepp.
European patent No 2288360 B1 (12.05.2009). Isolated microorganism strain Lactobacillus plantarum INDUCIA DSM 21379 as a probiotic that enhances natural immunity and food products and medicinal preparations comprising it. M. Mikelsaar, E. Songisepp, J. Stsepetova, P. Hütt, M. Zilmer, K. Truusalu, K. Kilk.
Patent: Cell penetrating peptides; CEPEP AB. Priit Kogerman, Mattias Hällbrink, Margus Pooga, Madis Metsis, Andres Valkna, Anne Meikas, Maria Lindgren, Astrid Gräslund, Claes Göran Östensson, Metka Budihna, Matjaz Zorko, Anna Elmquist, Ursel Soomets, Pontus Lundberg, Peter Järver, Külliki Saar, Samir El-Andaloussi, Kalle Kilk, Ülo Langel; SE20020001863; US20020391788P; 18.06.2002.

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Patendid: