Publikatsioonid ja patendid
Publikatsioonid
- Kepler T, Kuusik K, Lepner U, Starkopf J, Zilmer M, Eha J, Lieberg J, Vähi M, Kals J (2019) The Effect of Remote Ischaemic Preconditioning on Arterial Stiffness in Patients Undergoing Vascular Surgery: A Randomised Clinical Trial. Eur J Vasc Endovasc Surg. Jun;57(6):868-875. doi: 10.1016/j.ejvs.2018.12.002. Epub 2019 May 22.
- Balõtšev, Roman; Haring, Liina; Koido, Kati; Leping, Vambola, Kriisa, Kärt; Zilmer, Mihkel; Vasar, Veiko; Piir, Anneli; Lang, Aavo; Vasar, Eero (2019). Antipsychotic treatment is associated with inflammatory and metabolic biomarkers alterations among first-episode psychosis patients: A 7-month follow-up study. Early Intervention in Psychiatry, 13, 1−9.10.1111/eip.12457 [ilmumas].
- Nõmm, Monika; Porosk, Rando; Pärn, Pille; Kilk, Kalle; Soomets, Ursel; Kõks, Sulev; Jaakma, Ülle (2019). Invitro culture and non-invasive metabolic profiling of single bovine embryos. Reproduction Fertility and Development, 31 (2), 306−314.10.1071/RD17446.
- Jürgenson J, Serg M, Kampus P, Kals J, Zagura M, Viru M, Zilmer K, Zilmer M, Eha J, Unt E. (2019). Oxidative Stress Parameters and Its Associations With Arterial Stiffness in Competitive Powerlifting Athletes After 12-Week Supervised Strength Training. J Strength Cond Res. 2019 Jul;33(7):1816-1822. doi: 10.1519/JSC.0000000000003067.
- Leppik L, Parksepp M, Janno S, Koido K, Haring L, Vasar E, Zilmer M. (2019) Profiling of lipidomics before and after antipsychotic treatment in first-episode psychosis. Eur Arch Psychiatry Clin Neurosci. 2019 Jan 2. doi: 10.1007/s00406-018-0971-6. [Epub ahead of print].
- Vanaveski T, Narvik J, Innos J, Philips MA, Ottas A, Plaas M, Haring L, Zilmer M, Vasar E. (2018) Repeated Administration of D-Amphetamine Induces Distinct Alterations in Behavior and Metabolite Levels in 129Sv and Bl6 Mouse Strains. Front Neurosci. 2018 Jun 12; 12:399. doi: 10.3389/fnins.2018.00399. eCollection 2018
- Kairane, C.; Mahlapuu, R.; Porosk, R.; Zilmer, M.; Soomets, U. (2019). The effects of glutathione analogues on Na,K-ATPase activity in the kidneys of the wildtype and the Wfs1 gene mutated mice in vitro and in vivo. Journal of Peptide Science, 223−225.10.17952/35EPS.2018.223.
- Paapstel, Kaido; Kals, Jaak; Eha, Jaan; Tootsi, Kaspar; Ottas, Aigar; Piir, Anneli; Jakobson, Meelis; Lieberg, Jüri; Zilmer, Mihkel (2018). Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis. Nutrition, Metabolism and Cardiovascular Diseases, 28 (1), 44−52.10.1016/ j.numecd. 2017.07.011.
- Tootsi, Kaspar; Kals, Jaak; Zilmer, Mihkel; Paapstel, Kaido; Märtson, Aare (2018). Medium- and long-chain acylcarnitines are associated with osteoarthritis severity and arterial stiffness in end-stage osteoarthritis patients: a case-control study. International Journal of Rheumatic Diseases, 21 (6), 1211−1218.10.1111/1756-185X.13251.
- Leppik, Liisa; Kriisa, Kärt; Koido, Kati; Koch, Kadri; Kajalaid Kärolin; Haring, Liina; Vasar, Eero; Zilmer, Mihkel (2018). Profiling of Amino Acids and Their Derivatives Biogenic Amines Before and After Antipsychotic Treatment in First-Episode Psychosis. Frontiers in Psychiatry, 9, 155.10.3389/fpsyt.2018.00155.
- Teeäär, Tuuli; Serg, Martin; Paapstel, Kaido; Kals, Jaak; Kals, Mart; Zilmer, Mihkel; Eha, Jaan; Kampus, Priit (2018). Heart rate reduction decreases central blood pressure in sick sinus syndrome patients with a permanent cardiac pacemaker. Journal of Human Hypertension, 32 (5), 377−384.
- Ottas, Aigar; Fishman, Dmytro; Okas, Tiia-Linda; Kingo, Külli; Soomets, Ursel; (2017). The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease. Archives of Dermatological Research, 309 (7), 519−528.10.1007/s00403-017-1760-1.
- Porosk, R.; Mahlapuu, R.; Terasmaa, A.; Kilk, K.; Soomets, U. (2017). Glutathione system in Wolfram syndrome 1 deficient mice. Molecular Medicine Reports, 7092−7097.10.3892/ mmr.2017.7419.
- Porosk, R.; Terasmaa, A.; Mahlapuu, R.; Soomets, U.; Kilk, K. (2017). Metabolomics of the Wolfram Syndrome 1 Gene (Wfs1) Deficient Mice. OMICS A Journal of Integrative Biology, 21 (2), 721−732.omi.2017.0143.
- Ottas, Aigar; Fishman, Dmytro; Okas, Tiia-Linda; Püssa, Tõnu; Toomik, Peeter; Märtson, Aare, Kingo, Külli; Soomets, Ursel (2017). Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation. PLoS ONE, 12 (11), 1−14.10. 1371/ journal. pone. 0188580.
- Kriisa, Kärt; Leppik, Liisa; Balõtšev, Roman; Ottas, Aigar; Soomets, Ursel; Koido, Kati; Volke, Vallo; Innos, Jürgen; Haring, Liina; Vasar, Eero; Zilmer, Mihkel (2017). Profiling of Acylcarnitines in First Episode Psychosis before and after Antipsychotic Treatment. Journal of Proteome Research, 16 (10), 3558−3566.10.1021/acs.jproteome.7b00279.
- Kaspar Tootsi , Aare Märtson, Jaak Kals, Kaido Paapstel, Mihkel Zilmer (2017). Metabolic factors and oxidative stress in osteoarthritis: a case–control study. The Scandinavian Journal of Clinical and Laboratory Investigation, 77 (7), 520−526.10.1080/00365513.2017.1354255.
- Paapstel, Kaido; Zilmer, Mihkel; Eha, Jaan; Piir, Anneli; Tootsi, Kaspar; Kals, Jaak. (2016). Association between fibulin-1 and aortic augmentation index in male patients with peripheral arterial disease. European Journal of Vascular and Endovascular Surgery, 51, 76−82.
- Tootsi, Kaspar; Kals, Jaak; Zilmer, Mihkel; Paapstel, Kaido; Märtson, Aare (2016). Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness. International Journal of Rheumatology, 1−7.10.1155/2016/6402963.
- Paapstel, Kaido; Zilmer, Mihkel; Eha, Jaan; Tootsi, Kaspar; Piir, Anneli; Kals, Jaak (2016). Early biomarkers of renal damage in relation to arterial stiffness and inflammation in male coronary artery disease patients. Kidney & Blood Pressure Research, 41, 488−497.10.1159/000443450.
- Paapstel, Kaido; Kals, Jaak; Eha, Jaan; Tootsi, Kaspar; Ottas, Aigar; Piir, Anneli; Zilmer, Mihkel (2016). Metabolomic profiles of lipid metabolism, arterial stiffness and hemodynamics in male coronary artery disease patients. IJC Metabolic & Endocrine, 11, 13−18.10.1016/j.ijcme. 2016.05.001.
- Koido, Kati; Innos, Jürgen; Haring, Liina; Zilmer, Mihkel; Ottas, Aigar; Vasar, Eero (2016). Taurine and Epidermal Growth Factor Belong to the Signature of First-Episode Psychosis. Frontiers in Neuroscience, 10, 331−331.10.3389/fnins.2016.00331.
- Kaldur, Triin; Unt, Eve; Ööpik, Vahur; Zilmer, Mihkel; Eha, Jaan; Paapstel, Kaido; Kals, Jaak (2016). The acute effects of passive heat exposure on arterial stiffness, oxidative stress and inflammation. Medicina (Kaunas), 52, 211−216.
- Kullisaar, Tiiu; Zilmer, Kersti; Salum, Tiit; Rehema, Aune; Zilmer, Mihkel. (2016). The use of probiotic L. fermentum ME-3 containing Reg'Activ Cholesterol supplement for 4 weeks has a positive influence on blood lipoprotein profiles and inflammatory cytokines: an open-label preliminary study. Nutrition Journal, 93 (15, 1), 93−93.10.1186/s12937-016-0213-6.
- Tootsi, Kaspar; Kals, Jaak; Zilmer, Mihkel; Paapstel, Kaido; Märtson, Aare. (2016). Severity of osteoarthritis is associated with increased arterial stiffness. International Journal of Rheumatology, 1−7.10.1155/2016/6402963.
- Asser, Andres; Kõks, Sulev; Snellman, Anniina; Haaparanta-Solin, Merja; Arponen, Eveliina; Grönroos, Tove; Nairismägi, Jaak; Bergquist, Jonas; Soomets, Ursel; Piip, Piret; Eltermaa, Mall; Sauk, Martin; Lindmäe, Hanna; Rinne, Juha O; Taba, Pille (2016). Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese. Brain Research, 1652, 97−102.10.1016/j.brainres.2016.09.034.
Patendid
- Estonian Patent nr 05721 (19.08.2014). Isolee¬ritud mikro¬orga¬nis¬mide tüved Lactoba¬cillus plantarum MCC1 DSM 23881 ja selle kasutamine. T.Kullisaar , M. Zilmer, E. Tammsaar, A. Veski¬oja, E. Songisepp, K. Zilmer, L. Bobrovski, K. Ehrlich, M. Rät¬sep, M. Punab, M. Vasar, M. Mikelsaar.
- Patent of Russian Federation no 2486234. Isolated microorganism strain Lactobacillus plantarum INDUCIA DSM 21379 as a probiotic enhancing natural immunity, product and composition comprising said microorganism and use of said microorganism for medicinal preparation enhancing cellular immunity. M. Mikelsaar, E. Songisepp, I. Scmidt, J. Shepetova, P. Hütt, M. Zilmer, K. Truusalu, K. Kilk.
- Patent of Russian Federation no 2477750. Isolated microorganism strain Lactobacillus plantarum TENSIA DSM 21380 as antimicrobial and antihypertensive probiotic, food poducts and composition comprising said microorganism and use of said microorganism for preparation of antihypertensive medicine and method for suppressing pathogens and non-starter lactobacilli in food product. E. Songisepp, M. Mikelsaar, M. Rätsep, M. Zilmer, P. Hütt, M. Utt, M. K. Zilmer, J. Üksti, S. Kõljalg.
- Estonian patent EE 04580 (15.02.2006). Mikroorganismi tüvi Lactobacillus fermentum ME-3 kui antimikroobne ja antioksüdantne probiootikum, Microorganism strain L. Fermentum ME-3 as a novel antimicrobial and antioxidative probiotic. M. Mikelsaar, M. Zilmer, T. Kullisaar, H. Annuk, E.Songisepp.
- Patent of Russian Federation No RU 2284354 (26.09,2006). Probiotik, M. Mikelsaar, M. Zilmer, T. Kullissaar, H. Annuk, E.Songisepp.
- U.S. Patent No. 7244424 (17.07.2007). Strain of microrganism Lactobacillus fermentum ME-3 as a novel antimicrobial and antioxidative probiotic. M. Mikelsaar, M. Zilmer, T. Kullisaar, H. Annuk, E. Songisepp.
- Estonian Patent No 05340 (13.05.2008). Isoleeritud mikroorganismi tüvi Lactobacillus plantarum Tensia DSM 21380 ja selle kasutamine antimikroobse ja vererõhku alandava probiootikumina ning ravimi valmistamiseks ning toiduaine realiseerimisaja pikendamiseks ja toiduaines kontamineerivate mikroorganismide allasurumiseks, tüve sisaldav toiduaine ja kompositsioon. E.Songisepp, M. Mikelsaar, M. Rätsep, M. Zilmer, P. Hütt, M. Utt, K. Zilmer, J. Üksti, S. Kõljalg.
- Estonian Patent No 05341 (13.05.2008). Isoleeritud mikroorganismi tüvi Lactobacillus plantarum INDUCIA DSM 21379 kui organism loomulikku kaitsevõimat tõstev probiootik, seda sisaldav toiduaine ja kompositsioon ning mikroorganismi kasutamine rakulist immuunsust tõstva ravimi valmistamiseks. M. Mikelsaar, E. Songisepp, I. Smidt, J. Stsepetova, P. Hütt, M. Zilmer, K. Truusalu, K.Kilk.
- European Patent EP1401457B1 (01.12.2010). Strain of micro-organism Lactobacillus fermentum ME-3 as novel antioxidative probiotic., M. Mikelsaar, M. Zilmer, T. Kullissaar, H. Annuk, E. Songisepp.
- European patent No 2288360 B1 (12.05.2009). Isolated microorganism strain Lactobacillus plantarum INDUCIA DSM 21379 as a probiotic that enhances natural immunity and food products and medicinal preparations comprising it. M. Mikelsaar, E. Songisepp, J. Stsepetova, P. Hütt, M. Zilmer, K. Truusalu, K. Kilk.
- Patent: Cell penetrating peptides; CEPEP AB. Priit Kogerman, Mattias Hällbrink, Margus Pooga, Madis Metsis, Andres Valkna, Anne Meikas, Maria Lindgren, Astrid Gräslund, Claes Göran Östensson, Metka Budihna, Matjaz Zorko, Anna Elmquist, Ursel Soomets, Pontus Lundberg, Peter Järver, Külliki Saar, Samir El-Andaloussi, Kalle Kilk, Ülo Langel; SE20020001863; US20020391788P; 18.06.2002.