Publikatsioonid

2017

• Lepik K, Annilo T, Kukuškina V; eQTLGen Consortium, Kisand K, Kutalik Z, Peterson P, Peterson H. (2017) C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis. PLoS Comput Biol. 13: e1005766.
• Fishman D, Kisand K, Hertel C, Rothe M, Remm A, Pihlap M, Adler P, Vilo J, Peet A, Meloni A, Podkrajsek KT, Battelino T, Bruserud Ø, Wolff ASB, Husebye ES, Kluger N, Krohn K, Ranki A, Peterson H, Hayday A, Peterson P. (2017) Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. Front Immunol. 8: 976.
• Šahmatova L, Sügis E, Šunina M, Hermann H, Prans E, Pihlap M, Abram K, Rebane A, Peterson H, Peterson P, Kingo K, Kisand K. (2017) Signs of innate immune activation and premature immunosenescence in psoriasis patients. Scientific Reports. 7: 7553.
• Hermann H, Runnel T, Aab A, Baurecht H, Rodriguez E, Magilnick N, Urgard E, Šahmatova L, Prans E, Maslovskaja J, Abram K, Karelson M, Kaldvee B, Reemann P, Haljasorg U, Rückert B, Wawrzyniak P, Weichenthal M, Mrowietz U, Franke A, Gieger C, Barker J, Trembath R, Tsoi LC, Elder JT, Tkaczyk ER, Kisand K, Peterson P, Kingo K, Boldin M, Weidinger S, Akdis CA, Rebane A. (2017) miR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis. J Invest Dermatol. 137: 1945-1954.
• Kasela S, Kisand K, Tserel L, Kaleviste E, Remm A, Fischer K, Esko T, Westra HJ, Fairfax BP, Makino S, Knight JC, Franke L, Metspalu A, Peterson P, Milani L. (2017) Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells. PLoS Genet. 13: e1006643.
• Guha M, Saare M, Maslovskaja J, Kisand K, Liiv I, Haljasorg U, Tasa T, Metspalu A, Milani L, Peterson P. (2017) DNA breaks and chromatin structural changes enhance the transcription of autoimmune regulator target genes. J Biol Chem. 292: 6542-6554.
• Haljasorg U, Dooley J, Laan M, Kisand K, Bichele R, Liston A, Peterson P. (2017) Irf4 Expression in Thymic Epithelium Is Critical for Thymic Regulatory T Cell Homeostasis. J Immunol. 198: 1952-1960.

2016

• Meyer S, Woodward M, Hertel C, Vlaicu P, Haque Y, Kärner J, Macagno A, Onuoha SC, Fishman D, Peterson H, Metsküla K, Uibo R, Jäntti K, Hokynar K, Wolff AS, APECED patient collaborative, Krohn K, Ranki A, Peterson P, Kisand K, Hayday A. (2016) AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies. Cell. 166: 582-95.
• Kärner J, Pihlap M, Ranki A, Krohn K, Trebusak Podkrajsek K, Bratanic N, Battelino T, Willcox N, Peterson P, Kisand K. (2016) IL-6-specific autoantibodies among APECED and thymoma patients. Immun Inflamm Dis. 4: 235-243.
• Laan M, Haljasorg U, Kisand K, Salumets A, Peterson P. (2016) Pregnancy-induced thymic involution is associated with suppression of chemokines essential for T-lymphoid progenitor homing. Eur J Immunol. 46: 2008-2017.
• Bichele R, Kisand K, Peterson P, Laan M. (2016) TNF superfamily members play distinct roles in shaping the thymic stromal microenvironment. Mol Immunol. 72: 92-102.
• Hetemäki I, Jarva H, Kluger N, Baldauf HM, Laakso S, Bratland E, Husebye ES, Kisand K, Ranki A, Peterson P, Arstila TP. (2016) Anticommensal responses are associated with regulatory T cell defect in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy patients. J Immunol. 196: 2955-2964.
• Limbach M, Saare M, Tserel L, Kisand K, Eglit T, Sauer S, Axelsson T, Syvänen AC, Metspalu A, Milani L, Peterson P. (2016) Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling. J Autoimmun. 67: 46-56.

2015

• Haljasorg U, Bichele R, Saare M, Guha M, Maslovskaja J, Kõnd K, Remm A, Pihlap M, Tomson L, Kisand K, Laan M, Peterson P. (2015) A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in mice. Eur J Immunol. 45: 3246-3256. PMID: 26364592.
• Maslovskaja J, Saare M, Liiv I, Rebane A, Peterson P. (2015) Extended HSR/CARD domain mediates AIRE binding to DNA. Biochem Biophys Res Commun. 468: 913-20.
• Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T; NABEC/UKBEC Consortium, Ramos YF, Göring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MM, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe HJ, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra HJ, McRae AF, Smith JA, Kardia SL, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YD, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JB, Johnson AD. (2015) The transcriptional landscape of age in human peripheral blood. Nat Commun. 6: 8570.
• Kõks G, Uudelepp ML, Limbach M, Peterson P, Reimann E, Kõks S. (2015) Smoking-Induced Expression of the GPR15 Gene Indicates Its Potential Role in Chronic Inflammatory Pathologies. Am J Pathol. 185: 2898-2906.
• Saare M, Hämarik U, Venta R, Panarina M, Zucchelli C, Pihlap M, Remm A, Kisand K, Toots U, Möll K, Salupere R, Musco G, Uibo R, Peterson P. (2015) SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis. J Immunol Res. 2015: 526518.
• Tserel L, Kolde R, Limbach M, Tretyakov K, Kasela S, Kisand K, Saare M, Vilo J, Metspalu A, Milani L, Peterson P. (2015) Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes. Sci Rep. 5: 13107.
• Kisand K, Peterson P. (2015) Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. J Clin Immunol. 35: 463-478.
• Peterson P. (2015) Sirt-ainly Aire. Nature Immunol. 16: 680-681.
• Westra HJ, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, Li Y, Fu J, Karjalainen J, Platteel M, Visschedijk M, Weersma RK, Kasela S, Milani L, Tserel L, Peterson P, Reinmaa E, Hofman A, Uitterlinden AG, Rivadeneira F, Homuth G, Petersmann A, Lorbeer R, Prokisch H, Meitinger T, Herder C, Roden M, Grallert H, Ripatti S, Perola M, Wood AR, Melzer D, Ferrucci L, Singleton AB, Hernandez DG, Knight JC, Melchiotti R, Lee B, Poidinger M, Zolezzi F, Larbi A, Wang de Y, van den Berg LH, Veldink JH, Rotzschke O, Makino S, Salomaa V, Strauch K, Völker U, van Meurs JB, Metspalu A, Wijmenga C, Jansen RC, Franke L. (2015) Cell Specific eQTL Analysis without Sorting Cells. PLoS Genet. 11: e1005223.
• Falorni A, Bini V, Betterle C, Brozzetti A, Castaño L, Fichna M, Kämpe O, Mellgren G, Peterson P, Chen S, Rönnelid J, Seissler J, Tiberti C, Uibo R, Yu L, Lernmark Å, Husebye E. (2015) Determination of 21 hydroxylase autoantibodies: inter-laboratory concordance in the Euradrenal International Serum Exchange Program. Clin Chem Lab Med 53: 1761-1770.
• Pekkarinen PT, Heikkilä N, Kisand K, Peterson P, Botto M, Daha MR, Drouet C, Isaac L, Helminen M, Haahtela T, Meri S, Jarva H, Arstila TP. (2015) Dysregulation of adaptive immune responses in complement C3-deficient patients. Eur J Immunol. 45: 915-921.

2014

• Kisand K, Peterson P, Laan, M (2014). Lymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patients. Frontiers Immunology. 5: 1-10.
• Wolff AS, Kärner J, Owe JF, Oftedal BE, Gilhus NE, Erichsen MM, Kämpe O, Meager A, Peterson P, Kisand K, Willcox N, Husebye ES (2014). Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors. Journal of Immunology. 193: 3880-3890.
• Laakso S.M, Kekäläinen E, Heikkilä N, Mannerström H, Kisand K, Peterson P, Ranki A, Arstila T.P (2014). In vivo analysis of helper T cell responses in patients with autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy provides evidence in support of an IL-22 defect. Autoimmunity. 47: 556-562.
• Zucchelli C, Tamburri S, Quilici G, Palagano E, Berardi A, Saare M, Peterson P, Bachi A, Musco G (2014).Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1. FEBS Journal. 281: 216-231.
• Tserel L, Limbach M, Saare M, Kisand K, Metspalu A, Milani L, Peterson P (2014). CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing. Immunity and Ageing, 11: 1. 

2013

• Peterson P, Laan M (2013). Bipotency of thymic epithelial progenitors comes in sequence. Eur J Immunol. 43: 580-583.
• Kärner J, Meager A, Laan M, Maslovskaja J, Pihlap M, Remm A, Juronen E, Wolff AS, Husebye ES, Podkrajšek KT, Bratanic N, Battelino T, Willcox N, Peterson P, Kisand K (2013). Anti-cytokine autoantibodies suggest pathogenetic links with autoimmune regulator deficiency in humans and mice. Clin Exp Immunol. 171: 263-272.
• Kuparinen T, Marttila S, Jylhävä J, Tserel L, Peterson P, Jylhä M, Hervonen A, Hurme M (2013). Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: a transcriptomic analysis. Exp Gerontol. 48: 305-312.