Publikatsioonid ja patendid

Publikatsioonid

2020

• Haljasmägi L, Salumets A, Rumm AP, Jürgenson M, Krassohhina E, Remm A, Sein H, Kareinen L, Vapalahti O, Sironen T, Peterson H, Milani L, Tamm A, Hayday A, Kisand K, Peterson P. (2020) Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19. Sci Rep. 10: 20533.
• Naaber P, Hunt K, Pesukova J, Haljasmägi L, Rumm P, Peterson P, Hololejenko J, Eero I, Jõgi P, Toompere K, Sepp E. (2020) Evaluation of SARS-CoV-2 IgG antibody response in PCR positive patients: Comparison of nine tests in relation to clinical data. PLoS One. 15: e0237548.
• Kisand K, Peterson P. (2020) Metabolic fitness is decreased in monocytes of old individuals. Aging (Albany NY). 12: 18791-18792.
• Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen JI, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort, Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL. (2020) Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 370: eabd4585.
• Laing AG, Lorenc A, Del Molino Del Barrio I, Das A, Fish M, Monin L, Muñoz-Ruiz M, McKenzie DR, Hayday TS, Francos-Quijorna I, Kamdar S, Joseph M, Davies D, Davis R, Jennings A, Zlatareva I, Vantourout P, Wu Y, Sofra V, Cano F, Greco M, Theodoridis E, Freedman JD, Gee S, Chan JNE, Ryan S, Bugallo-Blanco E, Peterson P, Kisand K, Haljasmägi L, Chadli L, Moingeon P, Martinez L, Merrick B, Bisnauthsing K, Brooks K, Ibrahim MAA, Mason J, Lopez Gomez F, Babalola K, Abdul-Jawad S, Cason J, Mant C, Seow J, Graham C, Doores KJ, Di Rosa F, Edgeworth J, Shankar-Hari M, Hayday AC. (2020) A dynamic COVID-19 immune signature includes associations with poor prognosis. Nat Med. 26: 1623-1635.
• Haljasmägi L, Remm A, Rumm AP, Krassohhina E, Sein H, Tamm A, Kisand K, Peterson P. (2020) LIPS method for the detection of SARS-CoV-2 antibodies to spike and nucleocapsid proteins. Eur J Immunol. 50: 1234-1236.
• Kaleviste E, Rühlemann M, Kärner J, Haljasmägi L, Tserel L, Org E, Trebušak Podkrajšek K, Battelino T, Bang C, Franke A, Peterson P, Kisand K. (2020) IL-22 Paucity in APECED Is Associated with Mucosal and Microbial Alterations in Oral Cavity. Front Immunol. 11: 838.
• Carreras-Badosa G, Maslovskaja J, Periyasamy K, Urgard E, Padari K, Vaher H, Tserel L, Gestin M, Kisand K, Arukuusk P, Lou C, Langel Ü, Wengel J, Pooga M, Rebane A. (2020) NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation. Biomaterials. 262: 120316
• Saare M, Tserel L, Haljasmägi L, Taalberg E, Peet N, Eimre M, Vetik R, Kingo K, Saks K, Tamm R, Milani L, Kisand K, Peterson P. (2020) Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism. Aging Cell. 19: e13127.

2019

• Kaleviste E, Saare M, Leahy TR, Bondet V, Duffy D, Mogensen TH, Jørgensen SE, Nurm H, Ip W, Davies EG, Sauer S, Syvänen AC, Milani L, Peterson P, Kisand K. (2019) Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined. Eur J Immunol. 49: 790-800.
• Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G. et al. (2019) Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 49: 1457-1973.
• Yamano T, Dobeš J, Vobořil M, Steinert M, Brabec T, Ziętara N, Dobešová M, Ohnmacht C, Laan M, Peterson P, Benes V, Sedláček R, Hanayama R, Kolář M, Klein L, Filipp D. (2019) Aire expressing ILC3-like cells in the lymph node display potent APC features. J Exp Med. 216: 1027-1037.

2018

• Raam L, Kaleviste E, Šunina M, Vaher H, Saare M, Prans E, Pihlap M, Abram K, Karelson M, Peterson P, Rebane A, Kisand K, Kingo K. (2018) Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis. Front Immunol. 9: 2707.
• Weiler FG, Peterson P, Costa-Carvalho BT, de Barros Dorna M, Correia-Deur JE, Sader SL, Espíndola-Antunes D, Guerra-Junior G, Dias-da-Silva MR, Lazaretti-Castro M. (2018) The heterogeneity of autoimmune polyendocrine syndrome type 1: Clinical features, new mutations and cytokine autoantibodies in a Brazilian cohort from tertiary care centers. Clin Immunol. 197: 231-238.
• Cardoso AL, Fernandes A, Aguilar-Pimentel JA, de Angelis MH, Guedes JR, Brito MA, Ortolano S, Pani G, Athanasopoulou S, Gonos ES, Schosserer M, Grillari J, Peterson P, Tuna BG, Dogan S, Meyer A, van Os R, Trendelenburg AU. (2018) Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Res Rev. 47: 214-277.
• Ossart J, Moreau A, Autrusseau E, Ménoret S, Martin JC, Besnard M, Ouisse LH, Tesson L, Flippe L, Kisand K, Peterson P, Hubert FX, Anegon I, Josien R, Guillonneau C. (2018) Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease. J Immunol. 201: 874-887.
• Lalić IM, Bichele R, Repar A, Despotović SZ, Petričević S, Laan M, Peterson P, Westermann J, Milićević Ž, Mirkov I, Milićević NM. (2018) Lipopolysaccharide induces tumor necrosis factor receptor-1 independent relocation of lymphocytes from the red pulp of the mouse spleen. Ann Anat. 216: 125-134.
• Šunina M, Kaleviste E, Uibo R, Kisand K. (2018) Unstimulated Adult Human B Cells Include an IL-10+ Population with Suppressive Properties and an Activated Phenotype. Cytometry A. 93: 1150-1156.
• Bichele R, Kärner J, Truusalu K, Smidt I, Mändar R, Conti HR, Gaffen SL, Peterson P, Laan M, Kisand K. (2018) IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model. Eur J Immunol. 48: 464-470.
• Rodrigues PM, Peterson P, Alves NL. (2018) Setting Up the Perimeter of Tolerance: Insights into mTEC Physiology. Trends Immunol. 39: 2-5.

2017

• Lepik K, Annilo T, Kukuškina V; eQTLGen Consortium, Kisand K, Kutalik Z, Peterson P, Peterson H. (2017) C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis. PLoS Comput Biol. 13: e1005766.
• Fishman D, Kisand K, Hertel C, Rothe M, Remm A, Pihlap M, Adler P, Vilo J, Peet A, Meloni A, Podkrajsek KT, Battelino T, Bruserud Ø, Wolff ASB, Husebye ES, Kluger N, Krohn K, Ranki A, Peterson H, Hayday A, Peterson P. (2017) Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. Front Immunol. 8: 976.
• Šahmatova L, Sügis E, Šunina M, Hermann H, Prans E, Pihlap M, Abram K, Rebane A, Peterson H, Peterson P, Kingo K, Kisand K. (2017) Signs of innate immune activation and premature immunosenescence in psoriasis patients. Scientific Reports. 7: 7553.
• Hermann H, Runnel T, Aab A, Baurecht H, Rodriguez E, Magilnick N, Urgard E, Šahmatova L, Prans E, Maslovskaja J, Abram K, Karelson M, Kaldvee B, Reemann P, Haljasorg U, Rückert B, Wawrzyniak P, Weichenthal M, Mrowietz U, Franke A, Gieger C, Barker J, Trembath R, Tsoi LC, Elder JT, Tkaczyk ER, Kisand K, Peterson P, Kingo K, Boldin M, Weidinger S, Akdis CA, Rebane A. (2017) miR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis. J Invest Dermatol. 137: 1945-1954.
• Kasela S, Kisand K, Tserel L, Kaleviste E, Remm A, Fischer K, Esko T, Westra HJ, Fairfax BP, Makino S, Knight JC, Franke L, Metspalu A, Peterson P, Milani L. (2017) Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells. PLoS Genet. 13: e1006643.
• Guha M, Saare M, Maslovskaja J, Kisand K, Liiv I, Haljasorg U, Tasa T, Metspalu A, Milani L, Peterson P. (2017) DNA breaks and chromatin structural changes enhance the transcription of autoimmune regulator target genes. J Biol Chem. 292: 6542-6554.
• Haljasorg U, Dooley J, Laan M, Kisand K, Bichele R, Liston A, Peterson P. (2017) Irf4 Expression in Thymic Epithelium Is Critical for Thymic Regulatory T Cell Homeostasis. J Immunol. 198: 1952-1960.

2016

• Meyer S, Woodward M, Hertel C, Vlaicu P, Haque Y, Kärner J, Macagno A, Onuoha SC, Fishman D, Peterson H, Metsküla K, Uibo R, Jäntti K, Hokynar K, Wolff AS, APECED patient collaborative, Krohn K, Ranki A, Peterson P, Kisand K, Hayday A. (2016) AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies. Cell. 166: 582-95.
• Kärner J, Pihlap M, Ranki A, Krohn K, Trebusak Podkrajsek K, Bratanic N, Battelino T, Willcox N, Peterson P, Kisand K. (2016) IL-6-specific autoantibodies among APECED and thymoma patients. Immun Inflamm Dis. 4: 235-243.
• Laan M, Haljasorg U, Kisand K, Salumets A, Peterson P. (2016) Pregnancy-induced thymic involution is associated with suppression of chemokines essential for T-lymphoid progenitor homing. Eur J Immunol. 46: 2008-2017.
• Bichele R, Kisand K, Peterson P, Laan M. (2016) TNF superfamily members play distinct roles in shaping the thymic stromal microenvironment. Mol Immunol. 72: 92-102.
• Hetemäki I, Jarva H, Kluger N, Baldauf HM, Laakso S, Bratland E, Husebye ES, Kisand K, Ranki A, Peterson P, Arstila TP. (2016) Anticommensal responses are associated with regulatory T cell defect in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy patients. J Immunol. 196: 2955-2964.
• Limbach M, Saare M, Tserel L, Kisand K, Eglit T, Sauer S, Axelsson T, Syvänen AC, Metspalu A, Milani L, Peterson P. (2016) Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling. J Autoimmun. 67: 46-56.

Patendid

• Patentne leiutis: Human anti-IL-32 antibodies; Omanikud: Immunoqure AG; Autorid: Adrian Hayday, Kai Krohn, Annalisa Macagno, Shimobi Onuoha, Pärt Peterson, Mike Rothe, Martin Woodward, Syeda Haque, Kai Kisand; Prioriteedi number: EP20130174937 20130703; Prioriteedi kuupäev: 3.07.2013.
• Patentne leiutis: Human anti-IFN-alpha antibodies; Omanikud: Immunoqure AG; Autorid: Syeda Haque, Adrian Hayday, Kai Krohn, Annalisa Macagno, Steffen Meyer, Pärt Peterson, Mike Rothe, Philip Vlaicu, Martin Woodward, Kai Kisand; Prioriteedi number: EP20130174995 20130703; Prioriteedi kuupäev: 3.07.2013.
• Patentne leiutis: Method of providing monoclonal auto-antibodies with desired specificity; Omanikud: Immunoqure AG; Autorid: Adrian Hayday, Annamari Päivi Ranki, Pärt Peterson, Edward Stuart, Annalisa Macagno, Shimobi Onuoha, Kai Kisand; Prioriteedi number: US201314369467 20130102; Prioriteedi kuupäev: 28.12.2011.