-
Faculty of Arts and HumanitiesDean's Office, Faculty of Arts and HumanitiesJakobi 2, r 116-121 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of History and ArchaeologyJakobi 2 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of Estonian and General LinguisticsJakobi 2, IV korrus 51005 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Philosophy and SemioticsJakobi 2, III korrus, ruumid 302-337 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of Cultural ResearchÜlikooli 16 51003 Tartu linn, Tartu linn, Tartumaa EST0Institute of Foreign Languages and CulturesLossi 3 51003 Tartu linn, Tartu linn, Tartumaa EST0School of Theology and Religious StudiesÜlikooli 18 50090 Tartu linn, Tartu linn, Tartumaa EST0Viljandi Culture AcademyPosti 1 71004 Viljandi linn, Viljandimaa EST0Professors emeritus, Faculty of Arts and Humanities0Associate Professors emeritus, Faculty of Arts and Humanities0Faculty of Social SciencesDean's Office, Faculty of Social SciencesLossi 36 51003 Tartu linn, Tartu linn, Tartumaa EST0Institute of EducationJakobi 5 51005 Tartu linn, Tartu linn, Tartumaa EST0Johan Skytte Institute of Political StudiesLossi 36, ruum 301 51003 Tartu linn, Tartu linn, Tartumaa EST0School of Economics and Business AdministrationNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0Institute of PsychologyNäituse 2 50409 Tartu linn, Tartu linn, Tartumaa EST0School of LawNäituse 20 - 324 50409 Tartu linn, Tartu linn, Tartumaa EST0Institute of Social StudiesLossi 36 51003 Tartu linn, Tartu linn, Tartumaa EST0Narva CollegeRaekoja plats 2 20307 Narva linn, Ida-Virumaa EST0Pärnu CollegeRingi 35 80012 Pärnu linn, Pärnu linn, Pärnumaa EST0Professors emeritus, Faculty of Social Sciences0associate Professors emeritus, Faculty of Social Sciences0Faculty of MedicineDean's Office, Faculty of MedicineRavila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Biomedicine and Translational MedicineBiomeedikum, Ravila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of PharmacyNooruse 1 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of DentistryL. Puusepa 1a 50406 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Clinical MedicineL. Puusepa 8 50406 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Family Medicine and Public HealthRavila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Sport Sciences and PhysiotherapyUjula 4 51008 Tartu linn, Tartu linn, Tartumaa ESTprofessors emeritus, Faculty of Medicine0associate Professors emeritus, Faculty of Medicine0Faculty of Science and TechnologyDean's Office, Faculty of Science and TechnologyVanemuise 46 - 208 51003 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Computer ScienceNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa ESTInstitute of GenomicsRiia 23b/2 51010 Tartu linn, Tartu linn, Tartumaa ESTEstonian Marine Institute0Institute of PhysicsInstitute of ChemistryRavila 14a 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Mathematics and StatisticsNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0Institute of Molecular and Cell BiologyRiia 23, 23b - 134 51010 Tartu linn, Tartu linn, Tartumaa ESTTartu ObservatoryObservatooriumi 1 61602 Tõravere alevik, Nõo vald, Tartumaa EST0Institute of TechnologyNooruse 1 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Ecology and Earth SciencesJ. Liivi tn 2 50409 Tartu linn, Tartu linn, Tartumaa ESTprofessors emeritus, Faculty of Science and Technology0associate Professors emeritus, Faculty of Science and Technology0Area of Academic SecretaryHuman Resources OfficeÜlikooli 18, ruumid 302 ja 304 50090 Tartu linn, Tartu linn, Tartumaa EST0Area of Head of FinanceFinance Office0Area of Director of AdministrationInformation Technology Office0Administrative OfficeÜlikooli 17 (III korrus) 51005 Tartu linn, Tartu linn, Tartumaa EST0Estates Office0Marketing and Communication OfficeÜlikooli 18, ruumid 102, 104, 209, 210 50090 Tartu linn, Tartu linn, Tartumaa EST0Area of RectorRector's Strategy OfficeInternal Audit OfficeArea of Vice Rector for Academic AffairsOffice of Academic AffairsUniversity of Tartu Youth AcademyUppsala 10 51003 Tartu linn, Tartu linn, Tartumaa ESTStudent Union OfficeÜlikooli 18b 51005 Tartu linn, Tartu linn, Tartumaa EST0Centre for Learning and TeachingArea of Vice Rector for ResearchUniversity of Tartu LibraryW. Struve 1 50091 Tartu linn, Tartu linn, Tartumaa ESTGrant OfficeArea of Vice Rector for DevelopmentCentre for Entrepreneurship and InnovationNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0University of Tartu Natural History Museum and Botanical GardenVanemuise 46 51003 Tartu linn, Tartu linn, Tartumaa EST0International Cooperation and Protocol Office0University of Tartu MuseumLossi 25 51003 Tartu linn, Tartu linn, Tartumaa EST0
Reseach of the RNA Biology Research Group
24.11.2021
The main focus
Our ongoing research projects aim to elucidate the functions of RNA-based mechanisms in chronic inflammatory diseases, such as atopic dermatitis, psoriasis, and asthma. Specifically, we are interested in how miRNAs and RNA modifications regulate immune and epithelial cell responses, epithelial barrier functions, and proliferation and differentiation of epithelial cells in these diseases. Our second research goal is to develop more efficient and safe delivery methods for potentially therapeutic miRNAs and mRNA into immune cells and inflamed epithelium using cell-penetrating peptides. Additionally, we participate in collaborative projects that seek to discover and functionally characterize novel molecular factors involved in the development of chronic inflammatory skin diseases and asthma.
Grants
- Estonian Research Council: Adjustment of tissue-specific immune responses in chronic inflammatory diseases by miRNAs (Professor Ana Rebane, GMVBS21063PR, 01.01.2021−31.12.2025)
- European Commission, Horizon2020: Biomarkers in Atopic Dermatitis and Psoriasis (Professor Ana Rebane, MMVBS19122, 01.04.2019−31.03.2025)
- Estonian Research Council: Precision targeting of infiltrative glioblastoma (Research Fellow Pavel Kudrin, 01.09.2022−31.08.2024, SMVBS22358)
Recent publications
- Vaher H, Kingo K, Kolberg P, Pook M, Raam L, Laanesoo A, Remm A, Tenson T, Alasoo K, Mrowietz U, Weidinger S, Kingo K, Rebane A. Skin Colonization with S. aureus Can Lead to Increased NLRP1 Inflammasome Activation in Patients with Atopic Dermatitis. J Invest Dermatol. 2023 Feb 1:S0022-202X(23)00066-0. Online ahead of print.
- Carreras-Badosa G, Maslovskaja J, Vaher H, Pajusaar L, Annilo T, Lättekivi F, Hübenthal M, Rodriguez E, Weidinger S, Kingo K, Rebane A. miRNA expression profiles of the perilesional skin of atopic dermatitis and psoriasis patients are highly similar. Sci Rep. 2022 Dec 31;12(1):22645.
- Laanesoo A, Urgard E, Periyasamy K, Laan M, Bochkov YA, Aab A, Magilnick N, Pooga M, Gern JE, Johnston SL, Coquet JM, Boldin MP, Wengel J, Altraja A, Bochenek G, Jakiela B, Rebane A. Dual role of the miR-146 family in rhinovirus-induced airway inflammation and allergic asthma exacerbation. Clin Transl Med. 2021 Jun;11(6):e427. doi: 10.1002/ctm2.427.
- Carreras-Badosa G, Maslovskaja J, Periyasamy K, Urgard E, Padari K, Vaher H, Tserel L, Gestin M, Kisand K, Arukuusk P, Lou C, Langel Ü, Wengel J, Pooga M, Rebane A. NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation. Biomaterials. 2020 Aug 29;262:120316. doi: 10.1016/j.biomaterials.2020.120316. Online ahead of print.
- Vaher H, Runnel T, Urgard E, Aab A, Carreras Badosa G, Maslovskaja J, Abram K, Raam L, Kaldvee B, Annilo T, Tkaczyk ER, Maimets T, Akdis CA, Kingo K, Rebane A. miR-10a-5p is increased in atopic dermatitis and has capacity to inhibit keratinocyte proliferation. Allergy. 2019 May 2. [Epub ahead of print]
Call for abstracts: scientific conference celebrating the anniversary of the Faculty of Medicine
This year, the Faculty of Medicine's anniversary events will take place on October 10th and 11th. We invite all interested parties to submit abstracts for the Faculty of Medicine's anniversary research conference by May 27, 2024
Testicular maldescent in infertile men may be a sign of a more severe genetic syndrome
Surprisingly high fraction of infertile men presenting congenital testicular maldescent, were revealed as stated in a recent publication by researchers University of Tartu.
One of the largest male infertility genetic studies improves molecular diagnostics and personalized management of andrology patients
Approximately one in seven couples face difficulties conceiving a child naturally. Half of these cases are due to male infertility – either caused by the complete absence or low number of mature sperm.